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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Red cell distribution width and uric acid in patients with obstructive sleep apnea
Aysel Sunnetcioglu1, Hulya Gunbatar1, Hanifi Yıldız1
1Department of Chest Diseases, School of Medicine, Yuzuncu Yil University, Van, Turkey.
The Clinical Respiratory Journal
|March 16, 2017
Summary
Elevated red cell distribution width (RDW) and serum uric acid (SUA) are linked to obstructive sleep apnea (OSA) severity. Severe OSA patients showed higher RDW, especially those with cardiovascular disorders (CVDs).
Area of Science:
- Cardiology
- Sleep Medicine
- Biomarkers
Background:
- Obstructive sleep apnea (OSA) is linked to cardiovascular disorders (CVDs).
- Elevated red cell distribution width (RDW) and serum uric acid (SUA) are associated with CVDs and mortality.
- OSA is a significant risk factor for CVDs.
Purpose of the Study:
- To investigate serum uric acid (SUA) and red cell distribution width (RDW) levels in patients with obstructive sleep apnea (OSA).
- To determine the association between OSA severity and these biomarkers.
Main Methods:
- Retrospective study of 600 patients evaluated by polysomnography.
- Patients categorized into control, mild, moderate, and severe OSA groups based on apnea-hypopnea index (AHI).
Main Results:
- Severe OSA group exhibited significantly higher mean RDW and SUA compared to other groups.
- RDW correlated negatively with minimum SpO2 and positively with oxygen desaturation time.
- SUA showed a negative correlation with minimum SpO2.
- RDW was significantly higher in OSA patients with CVDs compared to those with OSA alone.
Conclusions:
- Elevated SUA and RDW levels are associated with obstructive sleep apnea (OSA) severity.
- RDW levels are significantly higher in patients with severe OSA and co-existing cardiovascular disorders (CVDs).
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