Nanoskin® Subcutaneous Implant in Guinea Pigs
Kryscia Natsuaki Kaminagakura1, Silvana Sue Sato1, Patricia Sugino1
1Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
Ophthalmic Plastic and Reconstructive Surgery
|March 16, 2017
Summary
Nanoskin, a bacterial cellulose biomaterial, shows promise for eyelid repair. This study found good tissue integration and mild inflammation, suggesting its potential as a posterior lamellar substitute.
Area of Science:
- Biomaterials Science
- Ophthalmology
- Regenerative Medicine
Background:
- The posterior lamellae of the eyelids are crucial for ocular surface protection.
- Current reconstructive options have limitations, necessitating the exploration of novel biomaterials.
Purpose of the Study:
- To assess the suitability of Nanoskin, a bacterial cellulose derivative, as a potential biomaterial for posterior eyelid lamellar repair.
- To evaluate the biocompatibility and tissue integration of Nanoskin implants in a preclinical model.
Main Methods:
- Nanoskin implants, with or without a gelatin coating, were subcutaneously implanted in guinea pigs.
- Animals were observed for up to 180 days, followed by histological, morphometric, and transmission electron microscopy analyses.
Main Results:
- Nanoskin demonstrated good tissue integration with the surrounding host tissue.
- A mild inflammatory response and the formation of a delicate pseudocapsule were observed around the implants.
- Results were comparable between Nanoskin and Nanoskin with a gelatin coating.
Conclusions:
- Nanoskin exhibits favorable biocompatibility and tissue integration, indicating its potential as a substitute for posterior eyelid lamellar tissue.
- Further clinical investigations are warranted to validate these preclinical findings for ophthalmic applications.
