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Association between polymorphisms in interleukins and oral lichen planus: A meta-analysis
1Institute of Stomatology, Chinese PLA General Hospital, Beijing, China.
Medicine
|March 16, 2017
Summary
This meta-analysis found no link between certain interleukin gene polymorphisms and oral lichen planus (OLP) risk. However, the IL10-592C/A polymorphism may be associated with an increased OLP risk.
Area of Science:
- Genetics
- Immunology
- Oral Medicine
Background:
- Emerging evidence suggests a correlation between single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes and an elevated risk of developing oral lichen planus (OLP).
- Previous findings on the association between IL gene polymorphisms and OLP risk have been inconsistent, necessitating further investigation.
Purpose of the Study:
- To conduct a comprehensive meta-analysis of existing clinical studies.
- To investigate the association between interleukin (IL) gene polymorphisms and the risk of oral lichen planus (OLP).
Main Methods:
- Systematic literature search of PubMed, Embase, and Cochrane Library for relevant studies.
- Meta-analysis of odds ratios (ORs) and 95% confidence intervals (CIs) to quantify the association.
- Statistical analysis performed using STATA software.
Main Results:
- Analysis included 6 studies, 4 SNPs (IL6-174G/C, IL10-592C/A, IL10-819C/T, IL10-1082G/A), 362 OLP patients, and 622 controls.
- No significant association was found for IL6-174G/C, IL10-819C/T, and IL10-1082G/A polymorphisms with OLP susceptibility.
- A significant association was identified for the IL10-592C/A polymorphism with OLP risk across multiple genetic models.
Conclusions:
- The meta-analysis did not establish a statistical association between IL6-174G/C, IL10-819C/T, and IL10-1082G/A polymorphisms and OLP susceptibility.
- The A allele and AA genotype of the IL10-592C/A polymorphism may be linked to an increased risk of OLP.
- Further well-designed studies with larger sample sizes are recommended to confirm these findings.
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