Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rheumatologic diseases in patients with inborn errors of immunity in the USIDNET registry.

Clinical rheumatology·2022

Same author

Professional Ethics.

The Dental register·2021

Same author

Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells.

Science immunology·2020

Same author

Chemical chaperones reverse early suppression of regulatory circuits during unfolded protein response in B cells from common variable immunodeficiency patients.

Clinical and experimental immunology·2019

Same author

Loss of B Cells in Patients with Heterozygous Mutations in IKAROS.

The New England journal of medicine·2016

Same author

Cross-reacting idiotypes in human sera.

Immunology today·2014

Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026

Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026

Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026

Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026

Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026

Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 12, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Chronic fatigue syndrome: a working case definition.

G P Holmes¹, J E Kaplan, N M Gantz

¹Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia.

Annals of Internal Medicine

|March 1, 1988

Summary

This summary is machine-generated.

Chronic Epstein-Barr virus syndrome, often causing fatigue, lacks consistent definition and a proven link to the virus. Researchers propose renaming it chronic fatigue syndrome, a syndrome of unknown cause, to improve research and patient evaluation.

More Related Videos

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Related Experiment Videos

Last Updated: May 12, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Area of Science:

Medical Research
Infectious Diseases
Psychiatry

Background:

Chronic Epstein-Barr virus syndrome presents as debilitating fatigue with diverse symptoms.
The syndrome's definition is inconsistent, and its link to Epstein-Barr virus is questionable.
Current diagnostic criteria and serologic tests for Epstein-Barr virus lack clear diagnostic value.

Purpose of the Study:

To propose a new name and working definition for chronic Epstein-Barr virus syndrome.
To improve the comparability and reproducibility of clinical research and epidemiologic studies.
To provide a rational basis for evaluating patients with chronic fatigue of undetermined cause.

Main Methods:

Literature review and critical analysis of existing diagnostic criteria.
Symptom complex analysis and reclassification.
Development of a new working definition for the proposed syndrome.

Main Results:

The term "chronic Epstein-Barr virus syndrome" is poorly defined and its causal link to Epstein-Barr virus is doubtful.
A new name, "chronic fatigue syndrome," is proposed to better describe the symptom complex.
A working definition for chronic fatigue syndrome is presented.

Conclusions:

The proposed "chronic fatigue syndrome" accurately reflects a primary symptom of chronic fatigue.
The new definition aims to standardize research and clinical evaluation for this condition.
Further research is needed to understand the etiology of chronic fatigue syndrome.