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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Frequency and Risk Factors of Clostridium difficile Infection in Hospitalized Patients With Pouchitis: A

Gaurav Kistangari1, Rocio Lopez, Bo Shen

  • 1*Department of Hospital Medicine, Medicine Institute, The Cleveland Clinic Foundation, Cleveland, Ohio; †Department of Quantitative Health Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio; and ‡Center for Inflammatory Bowel Diseases, The Cleveland Clinic Foundation, Cleveland, Ohio.

Inflammatory Bowel Diseases
|March 16, 2017
PubMed
Summary

Clostridium difficile infection (CDI) is rare in patients with ileal pouchitis due to familial adenomatous polyposis (FAP). Nonalcoholic fatty liver disease, obesity, and sleep apnea increase CDI risk in inflammatory bowel disease (IBD) patients with pouchitis.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Surgical Outcomes

Background:

  • Clostridium difficile infection (CDI) is a growing concern in patients with ileal pouches following proctocolectomy.
  • Pouchitis, inflammation of the ileal pouch, presents a specific context for evaluating CDI.
  • Understanding CDI prevalence and risk factors in this population is crucial for patient management.

Purpose of the Study:

  • To determine the frequency of CDI in patients diagnosed with pouchitis.
  • To identify risk factors associated with CDI in patients with pouchitis, particularly those with underlying inflammatory bowel disease (IBD).

Main Methods:

  • Utilized the National Inpatient Sample database (2010-2012) to identify patients with pouchitis.
  • Included patients with underlying inflammatory bowel disease (IBD) or familial adenomatous polyposis (FAP).
  • Analyzed concomitant diagnoses for CDI and performed multivariable analysis for risk factors in IBD patients.

Main Results:

  • A total of 3566 pouchitis patients were analyzed; 2.5% had CDI.
  • CDI occurred in 2.6% of pouchitis patients with IBD, but none with FAP.
  • Nonalcoholic fatty liver disease, obesity, and obstructive sleep apnea were significant risk factors for CDI in IBD patients with pouchitis.

Conclusions:

  • CDI in ileal pouchitis appears limited to patients with underlying IBD, being rare in FAP patients.
  • Nonalcoholic fatty liver disease, obesity, and obstructive sleep apnea are identified as key risk factors for CDI in IBD patients with pouchitis.