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Related Concept Videos

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: Mar 6, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Revisiting Terminology and Characteristics of Stem Cells.

A V Pechersky1

  • 1North-West State Medical University named after I.I. Mechnicov, St. Petersburg, Russia.

Journal of Stem Cells
|March 16, 2017
PubMed
Summary

Tissue regeneration throughout life relies on pluripotent stem cells, not differentiated or progenitor cells. These stem cells, guided by the immune system, commit to specific tissues, enabling continuous renewal.

Area of Science:

  • Developmental biology
  • Stem cell biology
  • Immunology

Background:

  • Differentiated and progenitor cells have limited regenerative capacity throughout an organism's lifespan.
  • Continuous tissue renewal necessitates a specialized regenerative system.
  • Pluripotent stem cells are crucial for lifelong tissue regeneration.

Purpose of the Study:

  • To elucidate the origin and commitment process of pluripotent stem cells.
  • To define the role of the immune system in stem cell differentiation.
  • To explain the mechanism of tissue regeneration via stem cell migration and differentiation.

Main Methods:

  • Conceptual framework based on developmental biology principles.
  • Analysis of stem cell differentiation pathways.
Keywords:
immune systempluripotent stem cellsregeneration

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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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  • Integration of immunological interactions in stem cell commitment.

    • Main Results:

    • Pluripotent stem cells originate from the fertilized egg's developmental program.
    • The immune system facilitates the formation of tissue-specific receptors on pluripotent stem cells.
    • Stem cells commit to tissue-specific lineages upon receptor formation, migrating to replenish progenitor cells.

    Conclusions:

    • Pluripotent stem cells are distinct from embryonic cells and are essential for sustained tissue regeneration.
    • Immune system involvement is critical for directing stem cell commitment.
    • Committed stem cells orchestrate tissue repair by migrating and differentiating, with mesenchymal stem cells supporting this process.