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Related Experiment Videos

Large bowel cancer in the young.

H C Umpleby1, R C Williamson

  • 1University Department of Surgery, Bristol Royal Infirmary, U.K.

Annals of the Academy of Medicine, Singapore
|July 1, 1987
PubMed
Summary
This summary is machine-generated.

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Younger patients (≤40 years) with colorectal carcinoma have similar survival rates to older patients, with radical resection improving outcomes. Early diagnosis and treatment are crucial for better prognosis in this demographic.

Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • Colorectal carcinoma (CRC) is increasingly diagnosed in younger adults (<40 years).
  • Understanding the specific characteristics and outcomes of early-onset CRC is essential for optimizing patient management.
  • This study reviews a cohort of young patients diagnosed with CRC over a significant period.

Purpose of the Study:

  • To analyze the incidence, predisposing factors, and survival rates of colorectal carcinoma in patients aged 40 or younger.
  • To compare outcomes based on tumor location, histological type, presentation, and treatment modality.
  • To evaluate the long-term survival following radical resection in this patient group.

Main Methods:

  • Retrospective review of 85 patients aged 40 or less diagnosed with colorectal carcinoma over 32 years.

Related Experiment Videos

  • Analysis of incidence, predisposing factors (familial polyposis, inflammatory bowel disease, irradiation, pregnancy).
  • Evaluation of survival rates based on presentation (emergency vs. elective), tumor characteristics, and treatment (curative resection).

    • Main Results:

    • CRC in patients ≤40 years represented 2.5% of all large bowel cancers.
    • Common predisposing factors included familial polyposis; 1/3 presented as emergencies, often with obstruction.
    • Five-year survival was 41% overall, 59% after curative resection, with poorer outcomes for short symptom duration and rectal tumors.

    Conclusions:

    • Radical resection is indicated for resectable colorectal carcinoma in younger patients, offering significant long-term survival benefits.
    • Despite potential unfavorable pathological features, outcomes in young CRC patients are comparable to older populations, especially with timely intervention.
    • Early diagnosis and prompt surgical management are critical for improving survival in early-onset colorectal cancer.