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HLA-A*24:374-A novel allele encoding the HLA-A2403 specificity
J Rowlands1, T Climer1, C Harvey1
1Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Pontyclun, Wales, UK.
HLA
|March 16, 2017
Summary
A novel Human Leukocyte Antigen (HLA) allele, HLA-A*24:374, has been identified. It differs from HLA-A*24:03:01:01 by two bases, leading to a T163E amino acid substitution.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Polymorphisms in HLA alleles contribute to diverse immune capabilities.
Purpose of the Study:
- To report the discovery and characterization of a new HLA-A allele.
Main Methods:
- Sequence analysis of HLA gene.
- Comparison with known HLA allele sequences.
Main Results:
- A novel allele, HLA-A*24:374, was identified.
- This allele differs from HLA-A*24:03:01:01 by two nucleotide bases in exon 3.
- The identified base changes result in a single amino acid substitution (Threonine to Glutamic acid at position 163).
Conclusions:
- The characterization of HLA-A*24:374 expands the known HLA-A allele repertoire.
- This finding contributes to the understanding of HLA polymorphism and its implications in immunogenetics.
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