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Congenital cytomegalovirus infection: a cause of sensorineural hearing loss

C S Peckham1, O Stark, J A Dudgeon

  • 1Institute of Child Health, London.

Archives of Disease in Childhood
|December 1, 1987
PubMed

Insights

Congenital cytomegalovirus (CMV) infection is a significant cause of sensorineural hearing loss in children. Studies show CMV is prevalent in children with hearing impairment, highlighting its role in this condition.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Audiology

Background:

  • Congenital cytomegalovirus (CMV) infection is a leading cause of non-genetic sensorineural hearing loss in children.
  • An estimated 108 children with congenital CMV and bilateral sensorineural hearing loss are born annually in England and Wales, accounting for 12% of cases.

Purpose of the Study:

  • To investigate the prevalence of congenital CMV infection in children with sensorineural hearing loss.
  • To determine the association between CMV infection and the severity of hearing loss in young children.

Main Methods:

  • A nine-year prospective study screened 1644 children (6 months to 4 years) attending a specialized hearing and speech center.
  • CMV infection was diagnosed via urine screening.

Main Results:

  • The prevalence of CMV was nearly double (13%) in children with sensorineural hearing loss and no family history of deafness, compared to children with other forms of hearing impairment (7%) and those with normal hearing (7%).

Conclusions:

  • Congenital cytomegalovirus (CMV) is a significant etiological factor in pediatric sensorineural hearing loss.
  • Early screening for CMV in infants with hearing loss is crucial for timely diagnosis and intervention.

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