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Bioactive Lipids and Circulating Progenitor Cells in Patients with Cardiovascular Disease.

Salim S Hayek1, Yuri Klyachkin2, Ahmed Asfour2,3

  • 1Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

Stem Cells Translational Medicine
|March 16, 2017
PubMed
Summary

Plasma levels of sphingosine-1 phosphate (S1P) correlate with circulating progenitor cells (CPCs) in heart disease patients. This suggests S1P may be key in stem cell mobilization after cardiac injury.

Keywords:
Ceramide-1 phosphateCirculating progenitor cellCoronary artery diseaseMobilizationSphingosine-1 phosphate

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Area of Science:

  • Cardiovascular Biology
  • Stem Cell Biology
  • Lipid Metabolism

Background:

  • Bone marrow-derived progenitor cells mobilize after myocardial injury and in chronic ischemic heart disease.
  • Mechanisms driving progenitor cell mobilization remain poorly understood.
  • Circulating progenitor cells (CPCs) play a role in cardiac repair.

Purpose of the Study:

  • To investigate the relationship between plasma bioactive lipid levels and CPC counts.
  • To determine if sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) correlate with CPC numbers.
  • To explore the role of S1P in stem cell mobilization in cardiac patients.

Main Methods:

  • Quantified plasma S1P and C1P levels using mass spectrometry in 437 cardiac catheterization patients.
  • Assessed CPCs (CD34+, CD34+/CD133+, CD34+/CXCR4+) using flow cytometry.
  • Analyzed correlations between lipid levels and CPC counts, adjusting for confounding factors.

Main Results:

  • Plasma S1P levels significantly correlated with the numbers of CD34+, CD34+/CD133+, and CD34+/CXCR4+ CPCs.
  • No significant correlation was found between C1P levels and CPC counts.
  • S1P levels correlated with CPC counts in patients with coronary artery disease.

Conclusions:

  • S1P is mechanistically involved in stem cell mobilization in patients with cardiac disease.
  • S1P may represent a therapeutic target for enhancing endogenous stem cell mobilization.
  • Further research is warranted to investigate the therapeutic potential of S1P therapy for stem cell mobilization.