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Updated: Mar 6, 2026
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Published on: December 13, 2017
Long-Term Effective Thalamic Deep Brain Stimulation for Neuropathic Tremor in Two Patients with Charcot-Marie-Tooth
Lidia Cabañes-Martínez1, Marta Del Álamo de Pedro, Gema de Blas Beorlegui
1Functional Neurosurgery Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Background:
It has been described that many Charcot-Marie-Tooth syndrome type 2 patients are affected by a very disabling type of tremor syndrome, the pathophysiology of which remains unclear. Deep brain stimulation (DBS) has been successfully applied to treat most types of tremors by implanting electrodes in the ventral intermediate nucleus of the thalamus (Vim).
Methods:
We used DBS applied to the Vim in 2 patients with severe axonal inherited polyneuropathies who developed a disabling tremor.
Results:
Both patients responded positively to stimulation, with a marked reduction of the tremor and with an improvement of their quality of life.
Conclusion:
We report 2 cases of tremor associated with a hereditary neuropathy with a good response to DBS.
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