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[IgG4 immunohistochemistry in Riedle thyroiditis].

S Wang1, Y F Luo, J L Cao

  • 1Department of Pathology, Peking Union Medical College Hospital, Beijing 100730, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|March 16, 2017
PubMed
Summary
This summary is machine-generated.

Riedel thyroiditis (RT) shares pathological similarities with IgG4-related diseases (IgG4-RD). Immunohistochemical analysis reveals elevated IgG4-positive plasma cells and IgG4/IgG ratios in RT, suggesting some RT cases may be part of IgG4-RD.

Keywords:
Immunoglobulin GImmunohistochemistryThyroiditis

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Area of Science:

  • Endocrinology
  • Pathology
  • Immunology

Background:

  • Riedel thyroiditis (RT) is a rare thyroid disease characterized by extensive fibrosis.
  • The relationship between RT and IgG4-related diseases (IgG4-RD) remains unclear.
  • Understanding these connections is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To investigate the histopathological features of RT.
  • To examine the immunohistochemical expression of IgG4 in RT.
  • To explore the potential link between RT and IgG4-RD.

Main Methods:

  • Analysis of clinical and immunohistochemical data from 5 RT patients.
  • Histopathological examination of hematoxylin and eosin-stained thyroid tissue sections.
  • Immunohistochemical staining for IgG4 and IgG to determine cell counts and ratios.

Main Results:

  • RT cases showed fibrous hyperplasia with lymphocyte and plasma cell infiltration.
  • Phlebitis and eosinophils were observed in a subset of patients.
  • Elevated IgG4 counts and IgG4/IgG ratios were detected in RT tissues, with some cases meeting IgG4-RD diagnostic criteria.

Conclusions:

  • RT exhibits pathological similarities to IgG4-RD.
  • Increased IgG4-positive plasma cells and IgG4/IgG ratios in RT suggest a potential overlap.
  • Some RT cases may represent a manifestation of IgG4-RD.