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Related Experiment Video

Updated: Mar 6, 2026

Fabrication of a Solution-gated Indium-Tin-Oxide-based One-piece Transistor Enabling Sensitive Biosensing

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Published on: August 29, 2025

Ion Sensitive Transparent-Gate Transistor for Visible Cell Sensing.

Toshiya Sakata¹, Kotaro Nishimura¹, Yuuya Miyazawa¹

¹Department of Materials Engineering, School of Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan 113-8656.

Analytical Chemistry

|March 17, 2017

Summary

This summary is machine-generated.

We created an ion-sensitive transparent-gate transistor (IS-TGT) for cell sensing. This device offers simultaneous optical and electrical monitoring of cell functions, paving the way for cost-effective life science research.

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Area of Science:

Materials Science
Biotechnology
Sensor Technology

Background:

Developing advanced biosensors is crucial for real-time monitoring of cellular processes.
Existing methods often lack the ability to combine optical and electrical measurements.
Transparent electronics offer new possibilities for integrated bio-sensing platforms.

Purpose of the Study:

To develop a novel ion-sensitive transparent-gate transistor (IS-TGT) for visible cell sensing.
To evaluate the IS-TGT's performance in detecting pH, sodium, and potassium ions.
To demonstrate the potential of IS-TGT for simultaneous optical and electrical monitoring of cell functions.

Main Methods:

Fabrication of an IS-TGT using amorphous In-Ga-Zn-oxide (a-IGZO) and indium tin oxide (ITO) electrodes.
Characterization of the IS-TGT's transparency, pH response, and ion sensitivity.
Integration of the IS-TGT into a platform for simultaneous microscopic observation and electrical measurement.

Main Results:

The IS-TGT exhibited a pH response of approximately 56 mV/pH, close to a Nernstian response.
The device showed sensitivity to sodium and potassium ions relevant to biological environments.
The transparent nature of the IS-TGT allowed for concurrent optical and electrical analysis of cell activity.

Conclusions:

The developed IS-TGT is a promising tool for visible cell sensing.
Its ability to perform simultaneous optical and electrical measurements offers advantages for life science research.
The IS-TGT platform represents a simple, cost-effective solution for cell-sensing applications.