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Effects of two different lipid emulsions on morbidities and oxidant stress statuses in preterm infants: an

Sezin Unal1, Nihal Demirel1, Sara Erol1

  • 1a Department of Neonatology , Etlik Zubeyde Hanım Women's Teaching and Research Hospital , Ankara , Turkey.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|March 17, 2017
PubMed

Insights

This study compared SMOFlipid and ClinOleic in preterm infants, finding similar oxidative stress levels and no significant differences in morbidities like retinopathy of prematurity or chronic lung disease after use.

Area of Science:

  • Neonatal Medicine
  • Nutritional Science
  • Oxidative Stress Research

Background:

  • Preterm infants often require parenteral nutrition.
  • Evaluating lipid emulsions like SMOFlipid and ClinOleic is crucial for neonatal care.
  • Understanding their impact on oxidative stress and morbidities is essential.

Purpose of the Study:

  • To compare the effects of SMOFlipid and ClinOleic on oxidative stress markers.
  • To assess and compare the incidence of morbidities in preterm infants receiving these lipid emulsions.

Main Methods:

  • An observational study involving 227 very low birth weight preterm infants.
  • Infants received either SMOFlipid or ClinOleic for parenteral nutrition.
  • Oxidative stress was measured using total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) at baseline, week 1, and week 3.

Main Results:

  • No statistically significant differences in retinopathy of prematurity or chronic lung disease rates between the groups.
  • Oxidative stress markers (TAC, TOS, OSI) showed significant decreases in the ClinOleic group after 1 week.
  • While not statistically significant, the SMOFlipid group showed a trend towards increased TAC and decreased TOS/OSI.

Conclusions:

  • SMOFlipid and ClinOleic demonstrate comparable effects on oxidative stress markers once discontinued.
  • No significant differences in key neonatal morbidities were observed between the two lipid emulsions.
Abstract

Keywords:
Fish oilolive oiloxidative stresspretermtotal parenteral nutrition

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