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Updated: Mar 6, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Left Ventricular global longitudinal strain predicts heart failure readmission in acute decompensated heart failure

Simone Romano1,2, Ibrahim N Mansour1, Mayank Kansal1

  • 1Division of Cardiology, Department of Medicine, University of Illinois at Chicago, 840 S. Wood Street, M/C 715, Chicago, IL, 60612, USA.

Cardiovascular Ultrasound
|March 17, 2017
PubMed

Insights

Left ventricular global longitudinal strain (LV GLS) is a strong predictor of heart failure readmission. Worsening LV GLS indicates a higher risk of hospital readmission, even when ejection fraction is normal.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Acute decompensated heart failure (ADHF) frequently leads to hospital readmissions.
  • Predictive markers for heart failure (HF) readmission are crucial for patient management.

Purpose of the Study:

  • To evaluate if left ventricular (LV) global longitudinal strain (GLS) predicts HF readmission in ADHF patients.

Main Methods:

  • Assessed LV GLS using velocity vector imaging in 204 ADHF patients.
  • Followed patients for HF hospital readmissions up to 44 months.
  • Analyzed LV GLS as a predictor of readmission using multivariate analysis.

Main Results:

  • Worse LV GLS was significantly associated with higher HF readmission rates (log-rank p < 0.001).
  • LV GLS was the strongest independent predictor of recurrent HF readmission after adjusting for clinical factors.
  • Ejection fraction predicted readmission in univariate but not multivariate analysis.

Conclusions:

  • LV GLS is an independent predictor of HF readmission post-ADHF.
  • Progressive worsening of LV GLS signifies an increased risk of readmission.
  • LV GLS provides prognostic information beyond ejection fraction in ADHF.
Abstract

Keywords:
EchocardiographyHeart failureStrain analysis

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