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Related Concept Videos

Mesh Analysis with Current Sources01:10

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Mesh analysis becomes simpler when analyzing circuits with current sources, whether independent or dependent. The presence of current sources reduces the number of equations required for analysis. Two cases illustrate this:
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Characterizing Electron Transport through Living Biofilms
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Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis.

Geir Halnes1, Tuomo Mäki-Marttunen2, Klas H Pettersen3

  • 1Faculty for Science and Technology, Norwegian University of Life Sciences, Ås, Norway; geir.halnes@nmbu.no.

Journal of Neurophysiology
|March 17, 2017
PubMed
Summary
This summary is machine-generated.

Ionic diffusion can cause errors in standard current-source density (CSD) analysis of local field potentials (LFPs). An improved CSD method accounting for diffusion can eliminate these spurious findings.

Keywords:
current source densityelectrodiffusionextracellular potentialion diffusion

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Electrophysiology

Background:

  • Current-source density (CSD) analysis is standard for interpreting local field potentials (LFPs).
  • CSD analysis assumes extracellular currents are purely ohmic, ignoring ionic diffusion effects.
  • Ionic diffusion can cause slow potential shifts, especially with ion concentration gradients.

Purpose of the Study:

  • To investigate the impact of diffusion-evoked potential shifts on standard CSD analysis.
  • To determine if diffusion can lead to erroneous current source predictions.
  • To develop and validate an improved CSD method addressing diffusion effects.

Main Methods:

  • Biophysically realistic computer simulations of neuronal activity and extracellular potentials.
  • Comparison of standard CSD analysis with an improved CSD estimator accounting for concentration-dependent diffusion.
  • Analysis of simulated local field potentials under varying ionic conditions.

Main Results:

  • Diffusion-evoked potential shifts introduce significant errors into standard CSD analysis.
  • Unaccounted-for diffusion can lead to the prediction of spurious current sources.
  • The improved CSD estimator successfully removes diffusion-evoked prediction errors.

Conclusions:

  • Standard CSD analysis is susceptible to errors from ionic diffusion.
  • Accurate CSD analysis requires incorporating diffusion effects, particularly in vivo.
  • The developed CSD method offers a more reliable approach for electrophysiological recordings.