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Related Experiment Video

Updated: Mar 6, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

Dietary restriction increases variability in longevity.

A M Senior^1,2, S Nakagawa³, D Raubenheimer^4,5

¹Charles Perkins Centre, The University of Sydney, New South Wales 2006, Australia alistair.senior@sydney.edu.au.

Biology Letters

|March 17, 2017

Summary

This summary is machine-generated.

Early-life dietary restriction significantly increases lifespan variation, especially when experienced prenatally or into adulthood. This finding highlights how developmental nutrition impacts longevity variability.

Keywords:

caloric restriction early development lifespan meta-analysis nutrition variance

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Published on: January 7, 2013

Area of Science:

Longevity research
Developmental biology
Nutritional science

Background:

Nutritional environments during early life are linked to lifespan.
Previous studies show early-life dietary restriction can alter average longevity.
The impact of developmental diet on lifespan variability remains largely unexamined.

Purpose of the Study:

To investigate the effects of early-life dietary restriction on among-individual variance in longevity.
To analyze how developmental nutrition influences the variability of lifespan across individuals.

Main Methods:

Utilized emerging methods for meta-analysis of variance.
Synthesized data from cross-taxa studies on dietary restriction and longevity.
Quantified the standard deviation in longevity under different dietary conditions.

Main Results:

Early-life dietary restriction generally increases the standard deviation (s.d.) in longevity by approximately 8% compared to a standard diet.
Prenatal dietary restriction led to a 29% increase in longevity s.d.
Dietary restriction extending into adulthood resulted in a 36.6% increase in longevity s.d.

Conclusions:

Early-life dietary restriction significantly elevates variance in longevity.
The mechanisms, potentially involving resource acquisition or allocation, require further investigation.
Understanding developmental nutrition's role in longevity variability is crucial.