Related Experiment Video

Updated: Mar 6, 2026

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Complete Tumor Response with Afatinib 20 mg Daily in EGFR-Mutated Non-small Cell Lung Cancer: A Case Report

Raffaele Giusti1, Marco Mazzotta2, Daniela Iacono2

  • 1Medical Oncology Unit, Sant'Andrea Hospital of Rome, Via di Grottarossa 1035-39, 00189, Rome, Italy. raffaelegiusti@yahoo.it.

Clinical Drug Investigation
|March 17, 2017
PubMed

Insights

Low-dose afatinib (20 mg daily) effectively treated advanced EGFR-mutated non-small cell lung cancer (NSCLC) in a patient experiencing severe skin toxicities. This suggests low-dose afatinib is a viable option for NSCLC patients needing dose reduction.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used for EGFR-mutated non-small cell lung cancer (NSCLC).
  • Dosage reduction of afatinib is often necessary due to adverse events, but efficacy data for lower doses are limited.

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