Related Experiment Video

Updated: Mar 6, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.9K

Ascending aortic distensibility and target organ damage in primary hypertension without diabetes

Chong-Fu Jia1, Zhao-Qian Wang2, Xi-Xia Sun1

  • 1Department of Cardiovascular Radiology, The First Affiliated Hospital of Dalian Medical University, 222#, Zhong Shan Road, Dalian, 116011, Liaoning, China.

The International Journal of Cardiovascular Imaging
|March 17, 2017
PubMed

Insights

Reduced ascending aortic distensibility (AAD) is a significant predictor of hypertensive target organ damage (TOD). This finding suggests AAD measured via coronary CTA can aid in early detection of TOD in hypertension patients.

Area of Science:

  • Cardiovascular Imaging
  • Hypertension Research
  • Vascular Biology

Background:

  • Hypertension frequently leads to target organ damage (TOD).
  • Ascending aortic distensibility (AAD) reflects aortic health.
  • Early detection of TOD is crucial for managing hypertension.

Purpose of the Study:

  • To evaluate the relationship between AAD and hypertensive TOD.
  • To assess the predictive value of AAD for TOD.
  • To compare AAD with brachial-ankle pulse wave velocity (baPWV) in predicting TOD.

Main Methods:

  • Retrospective analysis of 167 primary hypertension patients undergoing coronary CTA.
  • Calculation of AAD from ECG-gated coronary CTA images.
  • Multivariate logistic regression to identify risk factors for TOD.

Main Results:

  • AAD and baPWV showed significant changes with TOD progression.
  • Lower AAD was independently associated with increased risk and severity of TOD.
  • AAD outperformed baPWV and other predictors in identifying TOD risk.

Conclusions:

  • Decreased AAD is an independent predictor of TOD in primary hypertension.
  • Coronary CTA-derived AAD offers a non-invasive method for early TOD detection.
  • AAD measurement provides valuable prognostic information beyond conventional methods.

Keywords:
Ascending aortaCTDistensibilityHypertensionTarget organ damage

More Related Videos

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions06:08

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

20.9K
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.8K

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.6K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
688
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.3K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
1.1K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.8K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
449