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Updated: Mar 6, 2026

Multimodality Diagnosis of Mesenteric Ischemia

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

Antral mucosal perfusion is not increased in GAVE.

Bezawit Tekola¹, Elliot Smith¹, James Mann¹

¹a The Division of Gastroenterology and Hepatology , University of Virginia , Charlottesville , VA , USA.

Postgraduate Medicine

|March 17, 2017

Summary

Gastric antral vascular ectasia (GAVE) does not increase antral blood flow, contrary to its appearance. A blood flow gradient exists between the stomach body and antrum in GAVE patients.

Keywords:

GAVE PPI anemia gastric mucosal perfusion watermelon stomach

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Area of Science:

Gastroenterology
Vascular Biology
Medical Physiology

Background:

Gastric antral vascular ectasia (GAVE) is a significant cause of gastrointestinal bleeding.
The underlying pathophysiology of GAVE, particularly concerning mucosal blood flow, remains poorly understood.

Purpose of the Study:

To investigate and compare gastric antral and body mucosal blood flow in patients with GAVE versus a control group.
To elucidate the role of mucosal perfusion in the pathogenesis of GAVE.

Main Methods:

Laser Doppler flowmetry (LDF) was employed to measure standardized mucosal blood flow rates.
Endoscopic LDF probe was used in 27 GAVE patients and 11 controls, assessing both antrum and gastric body.
Perfusion units (PU) were calculated to quantify blood flow.

Main Results:

Antral mucosal blood flow in GAVE patients (115.5 PU) was not significantly different from controls (123.7 PU), despite GAVE's hyperemic appearance.
A statistically significant gradient in blood flow was observed between the gastric body and antrum in GAVE patients (p < 0.001), which was absent in controls.

Conclusions:

Antral mucosal blood flow is not elevated in GAVE, challenging assumptions based on its visual characteristics.
A subtle but significant gradient between gastric body and antral blood flow in GAVE patients warrants further investigation into its pathophysiological implications.