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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
Published on: June 4, 2020
A New Perspective on the Risk of Hypercoagulopathy in Ovarian Hyperstimulation Syndrome Using Thromboelastography
Eyal Zohav1, Benny Almog1, Aviad Cohen1,2
11 Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Lis Maternity Hospital, Tel Aviv University, Tel Aviv, Israel.
Thromboelastography (TEG) can identify a hypercoagulable state in women with severe ovarian hyperstimulation syndrome (OHSS). This blood clot formation assessment reveals significant differences in coagulation indices, confirming hypercoagulability in OHSS patients.
Area of Science:
- Reproductive endocrinology and hemostasis research.
Background:
- Ovarian hyperstimulation syndrome (OHSS) is associated with thrombotic complications.
- A hypercoagulable state may underlie the pathophysiology of severe OHSS.
Purpose of the Study:
- To investigate if thromboelastography (TEG) can detect a hypercoagulable state in women with severe OHSS.
- To compare TEG-derived coagulation indices between women with severe OHSS and controls.
Main Methods:
- A prospective case-control study involving 36 women with severe OHSS and 32 controls undergoing controlled ovarian hyperstimulation.
- Thromboelastography (TEG) was used to assess blood clot formation and viscoelastic properties.
Main Results:
- All coagulation indices measured by TEG were significantly different between the severe OHSS group and the control group.
- The median coagulation index was significantly higher in the OHSS group (3.6) compared to controls (1.45) (P < .001).
- TEG demonstrated a hypercoagulable state in women with severe OHSS.
Conclusions:
- Thromboelastography (TEG) is effective in identifying a hypercoagulable state in women experiencing severe OHSS.
- TEG assessment of hemostasis provides valuable insights into the hypercoagulable condition associated with severe OHSS.
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