Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Genomics02:02

Genomics

41.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.2K
Genetic Variation01:25

Genetic Variation

1.5K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.5K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.2K
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

64
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
64
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.8K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular pathways of kidney development and their applications to clinical research.

Kidney international·2025
Same author

Response to Letter to Editor by A. Derbalah et al.: the role of automation in enhancing reproducibility and interoperability of PBPK models.

Briefings in bioinformatics·2025
Same author

Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression.

Orphanet journal of rare diseases·2025
Same author

A collaborative network analysis for the interpretation of transcriptomics data in Huntington's disease.

Scientific reports·2025
Same author

Making PBPK models more reproducible in practice.

Briefings in bioinformatics·2024
Same author

The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data.

ALTEX·2024
Same journal

Quercetin and low-dose gamma irradiation modulate oxidative stress, inflammation, autophagy, and apoptosis in DEN-induced hepatocarcinogenesis.

Genes & nutrition·2026
Same journal

Incorporating dietary information to enhance polygenic prediction models with applications to body mass index and type 2 diabetes.

Genes & nutrition·2026
Same journal

Effects of synbiotic supplementation on oxidative stress biomarkers in adults: an updated GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

Genes & nutrition·2026
Same journal

Camelina seeds and their glucosinolate, glucocamelinin, counteract severe fatty liver in rodents with monogenic obesity.

Genes & nutrition·2026
Same journal

A flexible synthetic diet platform for Drosophila nutrigenomics.

Genes & nutrition·2026
Same journal

Common genetic variants in vitamin D metabolism-related genes affect gut microbiota diversity in postmenopausal women.

Genes & nutrition·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.5K

Connecting the Human Variome Project to nutrigenomics.

Jim Kaput1, Chris T Evelo2, Giuditta Perozzi3

  • 1Division of Personalised Nutrition and Medicine, FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 USA.

Genes & Nutrition
|March 17, 2017
PubMed
Summary
This summary is machine-generated.

Nutrigenomics studies gene-nutrient interactions, a complex field. The Human Variome Project (HVP) aids in identifying genetic variations linked to nutrition-related diseases, enhancing research through standardized data.

Keywords:
HarmonizationHuman Variome ProjectNutrigenomics

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.6K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.4K

Related Experiment Videos

Last Updated: Mar 6, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.5K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.6K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.4K

Area of Science:

  • Nutrigenomics and Human Genetics

Background:

  • Nutrigenomics investigates complex gene-nutrient interactions influenced by genetic and environmental diversity.
  • Significant human genetic variation remains uncharacterized, hindering understanding of disease etiology.
  • Identifying DNA variants is crucial for comprehending nutrition-related disease risks.

Purpose of the Study:

  • To highlight the importance of the Human Variome Project (HVP) in advancing nutrigenomic research.
  • To emphasize the role of HVP in systematically identifying gene variants associated with human diseases and phenotypes.
  • To underscore the necessity of HVP's guidelines for harmonizing novel sequence data generated by next-generation sequencing in nutrigenomics.

Main Methods:

  • Leveraging the Human Variome Project (HVP) as an international collaborative framework.
  • Utilizing next-generation sequencing (NGS) methodologies to explore undiscovered human genome variations.
  • Applying HVP guidelines to standardize the collection and analysis of genetic and phenotypic data.

Main Results:

  • The HVP provides a systematic approach to cataloging gene mutations and variants.
  • Nutrigenomic studies benefit from HVP's infrastructure for analyzing gene-nutrient interactions.
  • Emerging NGS technologies will generate substantial new data, requiring HVP's harmonization efforts.

Conclusions:

  • The Human Variome Project is an essential partner for nutrigenomics research.
  • Standardized data from HVP is critical for understanding gene-nutrient interactions and disease risk.
  • Collaboration with HVP will ensure the effective utilization of new genomic data for advancing personalized nutrition and health.