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Updated: Mar 6, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
A highly selective colorimetric and fluorescent dual-modal probe for the rapid determination of fluoride anions
Changsuo Li1, Chengcheng Tang2, Liting Xing2
1Shandong Provincial Geo-mineral Engineering Exploration Institute, Jinan, China.
Abstract:
In this work, 4-(p-hydroxybenzylidenehydrazino)-N-butyl-1,8-naphthalimide (1) has been designed and synthesized as a colorimetric and fluorescent dual-modal probe for F- . Compound 1 immediately detected inorganic fluoride salts using UV/vis absorption and fluorescence spectroscopy methods, and served as a 'naked-eye' indicator for F- with high selectivity and sensitivity. Both the absorption and fluorescence spectra show excellent linearity with the concentration of F- . Real-life applications demonstrated that our proposed analytical system provided a satisfactory method for the determination of F- . In addition, the reaction mechanism of deprotonation was confirmed by 1 H NMR.
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