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A planar symmetry of charge density is obtained when charges are uniformly spread over a large flat surface. In planar symmetry, all points in a plane parallel to the plane of charge are identical with respect to the charges. Suppose the plane of the charge distribution is the xy-plane, and the electric field at a space point P with coordinates (x, y, z) is to be determined. Since the charge density is the same at all (x, y) - coordinates in the z = 0 plane, by symmetry, the electric field at P...
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Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
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If a closed surface does not have any charge inside where an electric field line can terminate, then the electric field line entering the surface at one point must necessarily exit at some other point of the surface. Therefore, if a closed surface does not have any charges inside the enclosed volume, then the electric flux through the surface is zero. What happens to the electric flux if there are some charges inside the enclosed volume? Gauss's law gives a quantitative answer to this question.
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Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
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Related Experiment Video

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Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
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Efficient independent planar dose calculation for FFF IMRT QA with a bivariate Gaussian source model.

Feifei Li1, Ji-Yeon Park1, Brendan Barraclough1,2

  • 1Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.

Journal of Applied Clinical Medical Physics
|March 17, 2017
PubMed
Summary

This study developed an efficient algorithm for flattening filter-free (FFF) intensity-modulated radiotherapy (IMRT) quality assurance (QA). The new method accurately calculates planar dose distributions, improving FFF IMRT QA.

Keywords:
IMRT QAflattening filter freeindependent dose calculationsource model

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Physics

Background:

  • Flattening filters (FF) in photon beams significantly contribute to head scatter.
  • Flattening filter-free (FFF) beams offer potential advantages in radiotherapy but require accurate dose calculation methods for quality assurance (QA).
  • Independent dose calculation algorithms are crucial for verifying treatment plans in intensity-modulated radiotherapy (IMRT).

Purpose of the Study:

  • To directly compare source models for photon beams with and without flattening filters (FF).
  • To develop an efficient, independent algorithm for planar dose calculation in flattening filter-free (FFF) intensity-modulated radiotherapy (IMRT) quality assurance (QA).

Main Methods:

  • Developed a source model using a point source and Gaussian functions for primary photons and scatter.
  • Calculated IMRT beam fluence using backprojection and integration; modeled FFF off-axis ratios with a polynomial.
  • Employed an analytical kernel (sum of Gaussian functions) for dose deposition and convolution for ionization chamber volume averaging.

Main Results:

  • Achieved good agreement for in-air output factors (Sc) in both FF (<0.25%) and FFF (<0.10%) beams.
  • Demonstrated significant reduction in head-scattered photons with FF removal (34.7% at 6 MV, 49.3% at 10 MV).
  • Validated the algorithm with FFF head-and-neck IMRT plans, achieving high passing rates (96.2% for 6 MV, 95.5% for 10 MV) with a 2%/2 mm gamma criterion.

Conclusions:

  • The developed source model accurately represents FF and FFF photon beams.
  • The efficient, independent planar dose calculation algorithm is suitable for FFF IMRT QA.
  • This algorithm facilitates accurate and reliable quality assurance for FFF IMRT.