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Updated: Sep 21, 2026
Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
[Markers of an inflammation and angiogenesis in chronic cerebrovascular diseases]
O N Voskresenskaya1, N B Zaharova2, J S Tarasova2
1Sechenov First Moscow State Medical University, Moscow, Russia.
Insights
Chronic cerebral ischemia (CCI) patients show decreased vascular endothelial growth factor (VEGF) alongside immunoinflammatory processes. This study highlights VEGF as a potential marker for understanding CCI progression.
Area of Science:
- Neuroscience
- Immunology
- Vascular Biology
Background:
- Chronic cerebral ischemia (CCI) is a significant neurological condition.
- Understanding the underlying pathological mechanisms is crucial for diagnosis and treatment.
- Additional vascular lesion markers may offer new diagnostic insights.
Purpose of the Study:
- To investigate the diagnostic significance of specific vascular lesion markers in patients with chronic cerebral ischemia (CCI).
- To assess the relationship between inflammation, angiogenesis, and CCI.
- To evaluate the role of vascular endothelial growth factor (VEGF) in the context of CCI.
Main Methods:
- Studied markers of inflammation, including MCP-1 and C-reactive protein (CRP).
- Assessed angiogenesis marker vascular endothelial growth factor (VEGF) in blood serum and plasma.
- Compared marker levels in 50 patients with CCI against 60 healthy controls.
Main Results:
- Patients with CCI exhibited decreased levels of vascular endothelial growth factor (VEGF) in both serum and plasma.
- The development of immunoinflammatory processes was observed in patients with CCI.
- A correlation was found between reduced VEGF content and ongoing immunoinflammatory processes in CCI patients.
Conclusions:
- The study indicates that reduced VEGF levels are associated with immunoinflammatory processes in chronic cerebral ischemia.
- VEGF may serve as a potential diagnostic marker for assessing the progression of CCI.
- Further research into these markers could improve diagnostic strategies for cerebrovascular diseases.
Aim:
To study the diagnostic significance of additional vascular lesion markers in patients with chronic cerebral ischemia (CCI).
Material And Methods:
Markers of inflammation (МСР-1, CRP) and angiogenesis (VEGF in blood serum and plasma) were studied in 50 patients with CCI and 60 healthy people.
Results And Conclusion:
It was shown that the development of immunoinflammatory processes in patients with CCI is accompanied by the decrease in the content of vascular endothelial growth factor in the serum and blood plasma.
