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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
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[Poststroke mania].
1Kuvatov Republican Clinical Hospital, Ufa, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|March 17, 2017
Summary
Post-stroke mania is rare, affecting less than 1% of patients, and often linked to right-hemisphere lesions. Diagnosis and treatment follow general principles for affective disorders.
Area of Science:
- Neurology
- Psychiatry
- Neuroscience
Background:
- Affective disorders, particularly depression, are common in post-stroke patients.
- Mania is a rare affective disorder observed in less than 1% of stroke survivors.
Purpose of the Study:
- To investigate the occurrence and characteristics of mania following stroke.
- To explore the potential neurobiological underpinnings of post-stroke mania.
Main Methods:
- Review of clinical cases and neuroimaging findings in post-stroke patients presenting with mania.
- Analysis of vascular territory and lesion location associated with mania development.
Main Results:
- Mania after stroke is infrequent but can occur across any vascular territory.
- Lesions in the right hemisphere are more commonly associated with the development of mania.
- Abnormalities in cortico-striato-thalamo-cortical circuitry are implicated in its pathogenesis.
Conclusions:
- Post-stroke mania, though rare, requires clinical recognition.
- Right-hemisphere lesions and disrupted neural circuitry are key factors.
- Standard diagnostic and treatment protocols for mania are applicable in the post-stroke context.
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