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[Anti-ischemia effect of enalapril in coronary heart disease. A randomized placebo-controlled double-blind study]
N Rietbrock1, P Thürmann, R Kirsten
1Abteilung für Klinische Pharmakologie, Universität Frankfurt, Main.
Insights
The angiotensin-converting enzyme (ACE) inhibitor enalapril demonstrated an anti-anginal effect in patients with coronary heart disease. Treatment with enalapril significantly reduced exercise-induced ST depression, indicating improved cardiac function.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Angina pectoris is a common symptom of coronary heart disease (CHD).
- Angiotensin-converting enzyme (ACE) inhibitors are a class of drugs used to treat cardiovascular diseases.
Purpose of the Study:
- To evaluate the anti-anginal efficacy of the ACE inhibitor enalapril in patients with CHD.
- To assess the effect of enalapril on exercise-induced ST depression.
Main Methods:
- A randomized, placebo-controlled, double-blind trial was conducted.
- 12 normotensive patients with proven coronary heart disease participated.
- Enalapril was administered at a dosage of 5 mg twice daily.
Main Results:
- A 22% reduction in exercise-induced ST depression was observed after the first dose of enalapril.
- After 15 days of treatment, ST depression decreased by 35% (P < 0.05).
Conclusions:
- Enalapril exhibits a significant anti-anginal effect in patients with coronary heart disease.
- The drug effectively reduces exercise-induced ST depression, suggesting improved myocardial oxygen supply-demand balance.
Abstract:
The anti-anginal effect of the ACE inhibitor enalapril, at a dosage of 5 mg twice a day, was tested in a randomised, placebo-controlled double-blind trial on 12 normotensive patients with proven coronary-heart disease. There was a reduction of exercise-induced ST depression by 22% already after the first dose of 5 mg. After 15 days of treatment the ST depression had decreased by 35% (P less than 0.05).