B₁ mapping for bias-correction in quantitative T₁ imaging of the brain at 3T using standard pulse sequences

B₁ mapping is important for many quantitative imaging protocols, particularly those that include whole-brain T₁ mapping using the variable flip angle (VFA) technique. However, B₁ mapping sequences are not typically available on many magnetic resonance imaging (MRI) scanners. The aim of this work was to demonstrate that B₁ mapping implemented using standard scanner product pulse sequences can produce B₁ (and VFA T₁ ) maps comparable in quality and acquisition time to advanced techniques.

Six healthy subjects were scanned at 3.0T. An interleaved multislice spin-echo echo planar imaging double-angle (EPI-DA) B₁ mapping protocol, using a standard product pulse sequence, was compared to two alternative methods (actual flip angle imaging, AFI, and Bloch-Siegert shift, BS). Single-slice spin-echo DA B₁ maps were used as a reference for comparison (Ref. DA). VFA flip angles were scaled using each B₁ map prior to fitting T₁ ; the nominal flip angle case was also compared.

The pooled-subject voxelwise correlation (ρ) for B₁ maps (BS/AFI/EPI-DA) relative to the reference B₁ scan (Ref. DA) were ρ = 0.92/0.95/0.98. VFA T₁ correlations using these maps were ρ = 0.86/0.88/0.96, much better than without B₁ correction (ρ = 0.53). The relative error for each B₁ map (BS/AFI/EPI-DA/Nominal) had 95^th percentiles of 5/4/3/13%.

Our findings show that B₁ mapping implemented using product pulse sequences can provide excellent quality B₁ (and VFA T₁ ) maps, comparable to other custom techniques. This fast whole-brain measurement (∼2 min) can serve as an excellent alternative for researchers without access to advanced B₁ pulse sequences.

1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2017;46:1673-1682.