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Related Experiment Video

Updated: May 9, 2026

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

MICROPERIMETRY IN BEST VITELLIFORM MACULAR DYSTROPHY.

Maurizio Battaglia Parodi¹, Niccolò Castellino¹, Pierluigi Iacono²

¹Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy.

Retina (Philadelphia, Pa.)

|March 17, 2017

Summary

Retinal sensitivity is reduced across all stages of Best vitelliform macular dystrophy (VMD). Microperimetry reveals complex macular abnormalities and fixation instability, correlating with disease severity and visual acuity.

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Area of Science:

Ophthalmology
Retinal Diseases
Macular Dystrophy

Background:

Best vitelliform macular dystrophy (VMD) is a genetic disorder affecting central vision.
Understanding VMD's impact on retinal function across its clinical spectrum is crucial.

Purpose of the Study:

To investigate retinal sensitivity in all clinical stages of Best vitelliform macular dystrophy (VMD).
To correlate microperimetric findings with disease stage and visual acuity.

Main Methods:

Prospective cross-sectional study of 32 VMD patients across five clinical stages.
Ophthalmologic examination including best-corrected visual acuity (BCVA) and microperimetry.
Analysis of retinal sensitivity alterations and fixation stability patterns.

Main Results:

Reduced mean retinal sensitivity observed in all VMD stages.
Similar sensitivity reductions noted in vitelliform, pseudohypopyon, and vitelliruptive stages within 10°.
Fixation stability correlated significantly with VMD stage and BCVA.

Conclusions:

VMD presents with complex microperimetric abnormalities affecting the entire macula.
Microperimetry is a valuable tool for assessing VMD patients.
Microperimetry may aid in evaluating future therapeutic interventions for VMD.