Factors associated with study completion in patients with premature acute coronary syndrome
Anthony W Austin1, Roxanne Pelletier2, Louise Pilote3
1Department of Social and Behavioral Sciences, University of Arkansas at Pine Bluff, Pine Bluff, Arkansas, United States of America.
Insights
Older age, higher social status, and absence of diabetes, smoking, or depression improve cardiovascular study completion. Targeting at-risk individuals can enhance participant retention in future research.
Area of Science:
- Cardiovascular Disease Research
- Clinical Trial Methodology
Background:
- Factors influencing study completion in young adults with premature acute coronary syndrome are not well understood.
- This study investigated psychosocial, clinical, and demographic predictors of study completion in this population.
Purpose of the Study:
- To identify key factors associated with 12-month study completion in patients with premature acute coronary syndrome (ACS).
- To inform strategies for improving participant retention in cardiovascular cohort studies.
Main Methods:
- Utilized data from 1213 patients (≤55 years, 30% women) enrolled in the GENESIS-PRAXY study.
- Assessed demographic, psychosocial, and clinical variables at baseline and followed patients for 12 months to determine study completion.
Main Results:
- 64.1% of patients completed the 12-month follow-up.
- Older age, higher subjective social status, absence of type II diabetes, non-smoking status, and absence of depression were independently associated with study completion.
Conclusions:
- Strategies targeting younger individuals, smokers, those with low social status, diabetes, or depression may improve participant follow-up.
- Identifying and addressing barriers to participation is crucial for successful cardiovascular research.
Background:
Factors associated with study completion in younger adults are not well understood. This study sought to describe psychosocial, clinical, and demographic features associated with completion of a study of men and women with premature acute coronary syndrome.
Methods:
As part of the GENdEr and Sex determInantS of cardiovascular disease: From bench to beyond-Premature Acute Coronary Syndrome (GENESIS-PRAXY) study, demographic, psychosocial, and clinical variables were assessed in 1213 patients hospitalized for acute coronary syndrome (≤ 55 years; 30% women). Patients were followed for 12 months. Dropouts withdrew from the study or were lost to follow-up after 12 months; completers were still enrolled after 12 months.
Results:
Of 1213 patients initially enrolled, 777 (64.1%) completed 12-month follow-up. Fully adjusted models suggested that being older (OR = 1.04, 95% CI [1.01, 1.06]), higher subjective social status within one's country (OR = 1.11, 95% CI [1.01, 1.22]), being free of type II diabetes, (OR = 0.66, 95% CI [0.45, 0.97]), non-smoking status (OR = 0.70, 95% CI [0.51, 0.95]) and being free of depression (OR = 1.52, 95% CI [1.11, 2.07]) were independently associated with study completion.
Conclusions:
Recruitment/retention strategies targeting individuals who smoke, are younger, have low subjective social status within one's country, have diabetes, or have depression may improve participant follow-up in cardiovascular cohort studies.
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