Involvement of the Na+/H+ antiporter in activation of rat platelets by collagen
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T Nakano1, K Hanasaki, H Arita
1Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka.
Journal of Biochemistry
|October 1, 1987
Abstract:
The rapid Ca2+ increase shown by quin2-loaded platelets was found to be an artifact, probably due to light scattering elicited by collagen. Further findings as to fura2-loaded platelets offered additional support, demonstrating that the initial activation of phospholipase A2 (PLA2) does not require cytoplasmic Ca2+ mobilization. A possible role of the Na+/H+ antiporter as a trigger for collagen-induced activation of PLA2 in rat platelets was presented for the first time.