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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

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Mechanisms of sphingosine 1-phosphate receptor signalling in cancer

Sathya Narayanan Patmanathan1, Wei Wang2, Lee Fah Yap1

  • 1Department of Oral and Craniofacial Sciences, Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Cellular Signalling
|March 18, 2017
PubMed

Insights

Sphingosine-1-phosphate (S1P) signaling, through its receptors (S1PRs), plays a critical role in cancer progression. Targeting S1P receptors and their pathways offers potential therapeutic strategies for cancer treatment.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Signaling

Background:

  • Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator.',
  • S1P exerts effects via five G protein-coupled receptors (S1P1-5).
  • S1P signaling regulates key cellular processes including proliferation, apoptosis, migration, and angiogenesis.

Purpose of the Study:

  • To review the role of individual S1P receptors (S1PRs) in cancer progression.
  • To discuss the interplay between S1PRs and other signaling pathways in carcinogenesis.
  • To explore the therapeutic potential of targeting S1PRs for cancer treatment.

Main Methods:

  • Literature review of existing research on S1P receptors in cancer.
  • Analysis of evidence for S1PR involvement in cancer progression.
  • Discussion of signaling cross-talk and therapeutic targeting strategies.

Main Results:

  • S1P receptor expression alterations and S1P-regulating enzymes contribute to oncogenesis.
  • Receptor cooperativity, interactions with receptor tyrosine kinases, and subcellular localization influence S1PR signaling in cancer.
  • Emerging evidence highlights cross-talk between S1PRs and other cellular pathways.

Conclusions:

  • S1P receptor signaling is significantly implicated in cancer development and progression.
  • Understanding S1PR interactions and signaling is crucial for cancer therapy.
  • Targeting S1PRs and their downstream pathways presents a promising avenue for novel cancer treatments.
Keywords:
CancerGPCRSphingosine 1-phosphate

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