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Promising Therapeutic Strategies for Mesenchymal Stem Cell-Based Cardiovascular Regeneration: From Cell Priming to

Seung Taek Ji1, Hyunyun Kim1, Jisoo Yun1

  • 1Laboratory for Vascular Medicine and Stem Cell Biology, Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea.

Stem Cells International
|March 18, 2017
PubMed

Insights

Mesenchymal stem cells (MSCs) show promise for cardiovascular regeneration but have low survival rates. Strategies like cell priming and tissue engineering aim to enhance MSC efficacy for treating ischemic cardiovascular diseases.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Biology
  • Stem Cell Therapy

Background:

  • Ischemic cardiovascular diseases are a leading cause of death globally.
  • Adult stem cell therapies, particularly mesenchymal stem cells (MSCs), offer potential for cardiovascular regeneration due to their immunomodulatory and vascular repair capabilities.
  • A significant challenge for MSC therapy is their low survival rate in ischemic environments.

Purpose of the Study:

  • To review current clinical applications of MSCs in treating cardiovascular diseases.
  • To highlight strategies for enhancing MSC therapeutic efficacy for cardiovascular regeneration.
  • To explore cell priming and tissue engineering approaches for improving MSC survival and function.

Main Methods:

  • Review of current literature on MSC-based cardiovascular regeneration.
  • Analysis of strategies for improving MSC survival and longevity in vivo.
  • Examination of cell priming techniques and tissue engineering approaches (scaffolds, 3D printing).

Main Results:

  • Mesenchymal stem cells (MSCs) possess properties suitable for cardiovascular regeneration.
  • Low survival rates of engrafted MSCs in ischemic lesions remain a critical limitation.
  • Cell priming and advanced tissue engineering strategies show potential to overcome MSC limitations.

Conclusions:

  • Mesenchymal stem cells (MSCs) are promising for cardiovascular regeneration but require enhanced therapeutic strategies.
  • Priming MSCs and utilizing tissue engineering approaches like scaffolds and 3D printing can improve their efficacy.
  • Further development in these areas is crucial for advancing MSC-based treatments for ischemic cardiovascular diseases.

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