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Related Experiment Videos

Postural exercise abnormalities in symptomatic patients with mitral valve prolapse.

T M Bashore1, C L Grines, D Utlak

  • 1Department of Medicine, Ohio State University, Columbus.

Journal of the American College of Cardiology
|March 1, 1988
PubMed
Summary

Women with mitral valve prolapse (MVP) show reduced exercise tolerance, particularly upright. Their left ventricular end-diastolic volume significantly decreases when upright during rest and exercise.

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Area of Science:

  • Cardiology
  • Exercise Physiology
  • Biomedical Engineering

Background:

  • Mitral valve prolapse (MVP) affects heart valve function.
  • Understanding exercise hemodynamics in symptomatic MVP is crucial.
  • Previous studies have not fully elucidated upright exercise responses in MVP.

Purpose of the Study:

  • To compare supine and upright exercise hemodynamics in symptomatic women with MVP.
  • To assess exercise tolerance and left ventricular volumes in MVP patients versus controls.
  • To investigate potential exercise-induced mitral regurgitation.

Main Methods:

  • Echocardiography and phonocardiography at rest (supine/upright).
  • Symptomatic MVP patients (Group I) and asymptomatic controls (Group II) underwent graded bicycle exercise.

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  • Simultaneous radionuclide angiography, catecholamine measurements, and hemodynamic data acquisition.

    • Main Results:

    • MVP patients had reduced exercise duration and maximal workload, especially upright.
    • No significant difference in catecholamines or ventricular stroke counts between groups.
    • MVP patients showed a marked decrease in left ventricular end-diastolic volume index when upright, persisting through exercise.

    Conclusions:

    • Symptomatic MVP is associated with impaired upright exercise tolerance.
    • Reduced left ventricular filling in the upright posture contributes to decreased cardiac output in MVP.
    • Exercise-induced mitral regurgitation was not evident in this cohort.