Lung cancer and β-glucans: review of potential therapeutic applications

Area of Science:

• Immunology
• Oncology
• Natural Products Chemistry

Background:

• Beta-glucans are natural polysaccharides found in bacterial and fungal cell walls.
• They possess known immunomodulatory and direct anticancer properties.
• Lung cancer remains a leading cause of cancer mortality worldwide, necessitating novel therapeutic strategies.

Purpose of the Study:

• To review and synthesize existing research on the therapeutic applications of beta-glucans in lung cancer.
• To evaluate the efficacy of beta-glucans in both primary and metastatic lung cancer models.
• To consolidate findings from studies published between 1991 and 2016.

Main Methods:

• Systematic literature review of scientific publications.
• Analysis of studies investigating beta-glucans' effects on lung cancer.
• Inclusion of research published from 1991 to 2016.

Main Results:

• Beta-glucans demonstrate potential in modulating the immune system to combat cancer.
• Evidence suggests direct anticancer effects, including suppression of tumor proliferation.
• Studies indicate therapeutic promise for beta-glucans in various lung cancer contexts.

Conclusions:

• Beta-glucans represent a promising natural therapeutic agent for lung cancer.
• Further research into beta-glucan-based immunotherapies for lung cancer is warranted.
• The immunomodulatory and direct anticancer effects of beta-glucans are key to their potential.