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Neoepitopes as cancer immunotherapy targets: key challenges and opportunities

Cory A Brennick1, Mariam M George1, William L Corwin1

  • 1Department of Immunology, & Carole & Ray Neag Comprehensive Cancer Center, University of Connecticut, School of Medicine, Farmington, CT 06030-1601, USA.

Immunotherapy
|March 18, 2017
PubMed

Insights

Harnessing the immune system to treat cancer shows promise. This review explores challenges and ongoing research in developing effective cancer immunotherapies targeting tumor-specific epitopes.

Area of Science:

  • Immunology
  • Oncology
  • Bioinformatics

Background:

  • Cancers can trigger specific host immune responses.
  • Recent advances in gene sequencing and bioinformatics enable cancer immunotherapy.
  • Understanding tumor-specific epitopes is crucial for effective treatment.

Purpose of the Study:

  • To review the current challenges in cancer immunotherapy.
  • To discuss ongoing research addressing these hurdles.
  • To highlight the potential of harnessing the immune system for cancer treatment.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of high-throughput gene sequencing data.
  • Bioinformatic approaches for epitope identification.

Main Results:

  • Significant progress in identifying tumor-specific MHC I restricted epitopes (neoepitopes).
  • Several fundamental questions remain unanswered for clinical application.
  • Active research is underway to overcome existing obstacles.

Conclusions:

  • Cancer immunotherapy holds great clinical potential.
  • Further research is essential to address remaining challenges.
  • Overcoming hurdles will unlock the full therapeutic capacity of cancer immunotherapies.
Keywords:
binding affinitycancer Immunotherapycheckpoint blockadeneoepitopevaccine

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