Related Experiment Video

Updated: Aug 4, 2026

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
06:39

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

7.0K

Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage

Hsin-Hsi Tsai1, Li-Kai Tsai1, Ya-Fang Chen2

  • 1Departments of Neurology, National Taiwan University Hospital, Taipei, Taiwan.

Scientific Reports
|March 18, 2017
PubMed

Insights

Cerebral microbleeds (CMBs) in patients with intracerebral hemorrhage (ICH) are linked to amyloid burden. Mixed and lobar CMB types show higher amyloid levels than deep CMB types, indicating amyloid deposition.

Area of Science:

  • Neurology
  • Neuroimaging
  • Biomarkers

Background:

  • Cerebral microbleeds (CMBs) are small hemorrhages in the brain.
  • The distribution of CMBs (lobar, deep, or mixed) can indicate underlying pathologies.
  • Understanding the link between CMBs and β-amyloid is crucial for diagnosing and managing conditions like Alzheimer's disease and intracerebral hemorrhage (ICH).

Purpose of the Study:

  • To investigate the correlation between the distribution patterns of CMBs and the burden of β-amyloid in patients diagnosed with primary intracerebral hemorrhage (ICH).
  • To determine if CMB distribution can serve as a predictive marker for cerebral β-amyloid deposition.

Main Methods:

  • Magnetic resonance (MR) susceptibility-weighted imaging was used to identify and categorize CMBs in 47 ICH patients.
  • 11C-Pittsburgh Compound B positron emission tomography (PET) was employed to quantify global and regional amyloid burden.
  • Patients were classified into lobar, mixed (lobar and deep), and deep CMB groups.

Main Results:

  • The mixed CMB type exhibited significantly higher global amyloid burden compared to the deep CMB type.
  • The lobar CMB type showed the highest global amyloid burden, significantly greater than the deep CMB type.
  • A higher ratio of lobar to deep CMBs was independently correlated with increased global and occipital amyloid burden.

Conclusions:

  • In primary ICH, lobar and mixed CMB types are associated with a greater cerebral β-amyloid burden compared to the deep CMB type.
  • The ratio of lobar to deep CMBs is a significant independent indicator of β-amyloid deposition in the brain.
  • These findings highlight the potential of CMB distribution patterns as biomarkers for amyloid pathology in ICH patients.

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K
Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections07:28

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Published on: May 19, 2022

4.8K

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...