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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Related Experiment Video

Updated: Mar 6, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
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Steroid intracochlear distribution differs by administration method: Systemic versus intratympanic injection.

Jong Joo Lee1, Jeong Hun Jang1, Oak-Sung Choo1

  • 1Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.

The Laryngoscope
|March 18, 2017
PubMed
Summary

Systemic steroid injections showed higher uptake in the spiral ganglia and organ of Corti. Intratympanic injections led to greater accumulation in the organ of Corti and lateral walls, with prolonged cochlear drug levels.

Keywords:
Drug deliverycochleadexamethasoneintraperitonealintratympanic

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Area of Science:

  • Otolaryngology
  • Pharmacology
  • Neuroscience

Background:

  • Steroids are crucial for treating inner ear conditions like sudden sensorineural hearing loss.
  • Administration routes include systemic and intratympanic (IT) injections.
  • Understanding steroid distribution in the cochlea is vital for effective treatment.

Purpose of the Study:

  • To compare intracochlear steroid distribution between systemic and IT administration.
  • To investigate the pharmacokinetic differences of steroids based on delivery method.

Main Methods:

  • An animal study using Sprague-Dawley rats.
  • Administration of fluorescein isothiocyanate-labeled dexamethasone (FITC-DEX) via intraperitoneal (IP) or IT injection.
  • Evaluation of cochlear uptake using immunohistochemistry and flow cytometry at multiple time points.

Main Results:

  • Steroid uptake observed in spiral ganglion cells (SGs), organ of Corti (OC), and lateral walls (LWs).
  • IP injections resulted in higher FITC-DEX uptake in SGs and OC.
  • IT injections led to greater accumulation in OC and LWs, with more prolonged cochlear presence.

Conclusions:

  • Significant differences exist in cochlear steroid distribution based on administration route.
  • Findings enhance understanding of steroid pharmacokinetics within the cochlea.
  • This research can inform optimized steroid delivery strategies for inner ear diseases.