The second-generation eCLIPs Endovascular Clip System: initial experience

Area of Science:

• Neurosurgery
• Interventional Neuroradiology
• Medical Devices

Background:

• Treatment of wide-necked intracranial aneurysms, especially at bifurcations, presents challenges with existing methods.
• High recanalization and complication rates are associated with current treatments for these complex aneurysms.

Purpose of the Study:

• To evaluate the evolution, safety, and efficacy of the second-generation eCLIPs (Endovascular Clip System) device for treating bifurcation aneurysms.
• To assess the device's performance in terms of deployment, complication rates, and long-term angiographic and clinical outcomes.

Main Methods:

• A registry study involving 13 international centers treated patients with the second-generation eCLIPs device.
• Data collected included aneurysm characteristics, procedural details, device coverage, coil retention, and patient follow-up (imaging and clinical).
• Follow-up assessed angiographic results using the modified Raymond-Roy Classification and need for re-treatment.

Main Results:

• Successful eCLIPs device placement was achieved in 76% of 33 treated patients, with a learning curve observed in early deployment.
• Low rates of periprocedural complications were noted, including transient ischemic attacks and asymptomatic thrombotic events.
• At an average 8-month follow-up, 81% of patients achieved a modified Raymond-Roy Classification of I or II, with 42.9% showing improvement in Raymond grade.

Conclusions:

• The second-generation eCLIPs device is a feasible treatment option for intracranial bifurcation aneurysms.
• Aneurysm occlusion rates achieved with eCLIPs are comparable to other bifurcation support devices in initial clinical series.
• The device shows promise for managing complex wide-necked aneurysms, particularly at bifurcation sites.