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BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort.

Nesli Avgan1, Heidi G Sutherland2, Lauren K Spriggens3

  • 1Genomics Research Centre, Chronic Disease and Ageing, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane 4059, Australia. nesli.avgan@qut.edu.au.

International Journal of Molecular Sciences
|March 18, 2017
PubMed
Summary

Brain-derived neurotrophic factor (BDNF) and its anti-sense transcript (BDNF-AS) may influence long-term visual memory. This study found genetic variants in BDNF and BDNF-AS associated with long-term visual memory performance in a larger cohort.

Keywords:
BDNFgenetics of memoryhuman memorylong-term visual memory

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Area of Science:

  • Neuroscience
  • Genetics
  • Cognitive Science

Background:

  • Brain-derived neurotrophic factor (BDNF) is crucial for cognitive functions, particularly learning and memory.
  • BDNF is essential for synaptic plasticity and the formation of long-term memories.
  • Previous research indicated a link between the BDNF Val66Met polymorphism and long-term visual memory in a small cohort.

Purpose of the Study:

  • To investigate the association between genetic variants in BDNF and its anti-sense transcript (BDNF-AS) and visual memory performance.
  • To extend previous findings by analyzing a larger cohort and multiple genetic variants.
  • To assess the impact of these genes on both immediate and long-term visual memory.

Main Methods:

  • Expanded a cohort to 597 healthy individuals.
  • Genotyped 34 single nucleotide polymorphisms (SNPs) across BDNF and BDNF-AS using Illumina OmniExpress BeadChip arrays.
  • Performed genetic association analyses with visual memory performance using Wechsler Memory Scale-Fourth Edition subtests (Visual Reproduction I and II).

Main Results:

  • No significant associations were found between BDNF/BDNF-AS variants and immediate visual memory (VR I).
  • Ten variants, including BDNF Val66Met (p=0.006), showed nominal association with long-term visual memory (VR II).
  • Three variants (two in BDNF, one in BDNF-AS) were significantly associated with long-term visual memory performance.

Conclusions:

  • The study suggests a potential role for both BDNF and its anti-sense transcript BDNF-AS in long-term visual memory.
  • Genetic variations in these loci may influence an individual's ability to retain visual information over time.
  • Further research is warranted to elucidate the specific mechanisms underlying this association.