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Cellular differentiation and morphogenesis in Cordylophora.

Fred A Diehl1

  • 1Department of Biology, University of Virginia, Charlottesville, Virginia.

Wilhelm Roux' Archiv Fur Entwicklungsmechanik Der Organismen
|March 18, 2017
PubMed
Summary
This summary is machine-generated.

X-irradiation destroyed interstitial cells in Cordylophora, impacting regeneration. However, both epidermal and gastrodermal cells can still form reciprocal cell types, enabling regeneration in combined tissues.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Interstitial cells are crucial for regeneration in cnidarians like Cordylophora.
  • X-irradiation is a known method to eliminate specific cell populations for experimental purposes.

Purpose of the Study:

  • To investigate the role of interstitial cells in Cordylophora regeneration after x-irradiation.
  • To determine the regenerative potential of epidermal and gastrodermal tissues following interstitial cell ablation.
  • To explore the capacity of reciprocal cell layers to form missing cell types.

Main Methods:

  • X-irradiation of Cordylophora to eliminate interstitial cells.
  • Isolation and reaggregation of coenosarc, epidermis, and gastrodermis.
  • Histological analysis and observation of regenerative capacity in treated and untreated tissues.
  • Reconstitution experiments combining different tissue types.

Main Results:

  • X-irradiation effectively destroyed interstitial cells in Cordylophora.
  • While x-irradiated coenosarc showed reduced regeneration, both normal and irradiated tissues could form hydranths and stolons, influenced by epidermal-gastrodermal ratios.
  • Isolated irradiated epidermis failed to form gastrodermis and regenerate, but could secrete perisarc.
  • Isolated gastrodermis, irradiated or not, failed to regenerate and disintegrated.
  • Combinations of normal epidermis with irradiated gastrodermis, and vice versa, yielded viable animals, with evidence of interstitial cell formation from dedifferentiating gland cells in the latter case.

Conclusions:

  • Cordylophora's epidermal and gastrodermal cells possess plasticity, capable of forming cell types of the reciprocal layer.
  • Interstitial cells are not essential for all regenerative processes, as epidermal and gastrodermal cells can compensate for their absence.
  • The study highlights the remarkable regenerative plasticity within Cordylophora tissues, even after significant cellular damage.