Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.9K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Modern therapy of pulmonary embolism with PERT and EKOS: an advantage also for in-hospital time?]

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same author

Early versus delayed EKOS thrombolysis in intermediate-high risk pulmonary embolism: a retrospective multicentre analysis.

Open heart·2026
Same author

Associations between thoracolumbar fascia deformation, erector spinae activity, and deadlift performance: a matched pairs study.

Journal of bodywork and movement therapies·2026
Same author

Audiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial.

JACC. Advances·2026
Same author

IL-1β modulates inflammatory response of human bone marrow-derived MSCs and neutrophil recruitment in vitro via NF-kB-associated signaling.

Stem cell research & therapy·2026
Same author

Outcomes of transcatheter edge-to-edge repair versus transcatheter valve replacement with the cardiovalve system for tricuspid regurgitation.

Clinical research in cardiology : official journal of the German Cardiac Society·2026

Related Experiment Video

Updated: Mar 6, 2026

Generation and Long-term Maintenance of Nerve-free Hydra
06:33

Generation and Long-term Maintenance of Nerve-free Hydra

Published on: July 7, 2017

13.0K

Morphogenetic substances in nerve-depletedhydra.

H Chica Schaller1, Cornelis J P Grimmelikhuijzen1, Tobias Schmidt1

  • 1European Molecular Biology Laboratory, Postfach 102209, D-6900, Heidelberg, Federal Republic of Germany.

Wilhelm Roux'S Archives of Developmental Biology
|March 18, 2017
PubMed
Summary
This summary is machine-generated.

Severely depleted nerve cells in Hydra still produce essential morphogenetic substances. Epithelial cells appear to have taken over this function from nerve cells.

Keywords:
Morphogenetic substancesNerve-depletedhydra

More Related Videos

Generation of Transgenic Hydra by Embryo Microinjection
09:10

Generation of Transgenic Hydra by Embryo Microinjection

Published on: September 11, 2014

14.8K
Measuring Glutathione-induced Feeding Response in Hydra
08:10

Measuring Glutathione-induced Feeding Response in Hydra

Published on: November 16, 2014

11.8K

Related Experiment Videos

Last Updated: Mar 6, 2026

Generation and Long-term Maintenance of Nerve-free Hydra
06:33

Generation and Long-term Maintenance of Nerve-free Hydra

Published on: July 7, 2017

13.0K
Generation of Transgenic Hydra by Embryo Microinjection
09:10

Generation of Transgenic Hydra by Embryo Microinjection

Published on: September 11, 2014

14.8K
Measuring Glutathione-induced Feeding Response in Hydra
08:10

Measuring Glutathione-induced Feeding Response in Hydra

Published on: November 16, 2014

11.8K

Area of Science:

  • Developmental biology
  • Cell biology
  • Hydra research

Background:

  • Nerve cells are traditionally considered the primary producers of morphogenetic substances in Hydra.
  • Understanding the cellular basis of regeneration and pattern formation in Hydra is crucial for developmental biology.

Purpose of the Study:

  • To investigate the role of nerve cells in producing morphogenetic substances in Hydra.
  • To determine if other cell types can compensate for nerve cell loss in morphogen production.

Main Methods:

  • Hydra were treated with colchicine to drastically reduce nerve cell populations.
  • Concentrations of head activator, head inhibitor, foot activator, and foot inhibitor were measured in depleted Hydra.
  • Chromatographic analysis was used to confirm the chemical identity of the substances.

Main Results:

  • Nerve-depleted Hydra (less than 1% of normal nerve cells) maintained normal or elevated levels of key morphogenetic substances.
  • These substances exhibited identical chromatographic properties to those found in normal Hydra.
  • Epithelial cells were the only remaining major cell type in the depleted Hydra.

Conclusions:

  • Epithelial cells in Hydra may compensate for nerve cell loss by producing essential morphogenetic substances.
  • This finding challenges the exclusive role of nerve cells in Hydra morphogen production.
  • The study suggests a remarkable plasticity in cell function during regeneration and development.