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Related Concept Videos

Somatosensation01:33

Somatosensation

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The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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Sensory Functions of the Skin01:16

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Determination01:51

Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Related Experiment Video

Updated: Mar 6, 2026

Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology
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Two different sets of cis elements regulate scute to establish two different sensory patterns.

Luc Leyns1, Christine Dambly-Chaudière1, Alain Ghysen1

  • 1Laboratoire de Génétique, Université Libre de Bruxelles, 67 rue des Chevaux, B-1640, Rhode-St-Genèse, Belgium.

Roux'S Archives of Developmental Biology : the Official Organ of the EDBO
|March 18, 2017
PubMed
Summary

The achaete-scute gene complex in Drosophila development involves two independent subpatterns for campaniform sensilla. The scute gene requires upstream control regions, unlike scute-dependent bristles which need downstream elements.

Keywords:
Achaete-scute complexCampaniform sensillaCis regulatory sitesDrosophila

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Area of Science:

  • Developmental biology
  • Genetics
  • Neuroscience

Background:

  • The achaete-scute gene complex is crucial for neurogenesis in Drosophila.
  • Campaniform sensilla are mechanosensory organs involved in detecting stress and strain on the wing blade.

Purpose of the Study:

  • To investigate the specific roles of the achaete and scute genes in patterning Drosophila wing campaniform sensilla.
  • To elucidate the regulatory mechanisms controlling the expression of these genes in sensilla development.

Main Methods:

  • Analysis of gene expression patterns.
  • Genetic manipulation of achaete and scute genes.
  • Observation of sensilla development in mutant Drosophila strains.

Main Results:

  • The complete pattern of campaniform sensilla arises from two independent subpatterns.
  • One subpattern is controlled by the achaete gene, the other by the scute gene.
  • The scute-dependent sensilla subpattern requires upstream regulatory regions, differing from scute-dependent bristles.

Conclusions:

  • The achaete-scute gene complex plays a dual role in patterning Drosophila wing sensilla.
  • Distinct regulatory mechanisms control scute-dependent sensilla and bristles.
  • Understanding these genetic pathways provides insights into developmental patterning and neurogenesis.