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High resolution G-banding analysis in aniridia.
1Department of Ophthalmology, Juntendo University, School of Medicine, Tokyo, Japan.
Ophthalmic Paediatrics and Genetics
|November 1, 1987
Summary
High-resolution G-banding analysis in infantile aniridia cases can detect chromosome 11 deletions. This screening aids in the early diagnosis of Wilms
Area of Science:
- Genetics
- Pediatric Oncology
Background:
- Aniridia, a rare genetic disorder, affects eye development.
- Wilms' tumor is a common childhood kidney cancer.
Observation:
- Eight cases of aniridia were analyzed using high-resolution G-banding.
- Two cases revealed a deletion on the short arm of chromosome 11.
Findings:
- One patient with aniridia and chromosome 11 deletion was diagnosed with early-stage Wilms' tumor.
- The tumor was successfully surgically removed.
Implications:
- High-resolution G-banding analysis is recommended for infantile aniridia.
- This genetic screening can facilitate early Wilms' tumor detection and treatment.