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Updated: Mar 6, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Thrombomodulin distribution during murine development.

Virginia A Ford¹, John E Wilkinson², Stephen J Kennel³

¹University of Tennessee, Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, Tennessee.

Roux'S Archives of Developmental Biology : the Official Organ of the EDBO

|March 18, 2017

Summary

This summary is machine-generated.

Thrombomodulin, a key protein in blood clot regulation, shows high expression in developing mouse organs. This suggests thrombomodulin plays a crucial role in embryonic development.

Keywords:

Angiogenesis Monoclonal Antibodies Murine development Thrombomodulin expression

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Area of Science:

Developmental Biology
Molecular Biology
Hematology

Background:

Thrombomodulin is a transmembrane glycoprotein regulating clot formation.
In adult mice, thrombomodulin is mainly on endothelial cells.
During embryonic development, its expression differs significantly.

Purpose of the Study:

To investigate thrombomodulin expression patterns during mouse development.
To compare embryonic thrombomodulin localization with adult expression.

Main Methods:

Examined thrombomodulin expression in adult mice.
Analyzed thrombomodulin expression throughout murine development (Day 7.5 to 18.5).

Main Results:

High thrombomodulin expression observed in embryonic lung bud, gonads, leptomeninges, and parietal endoderm.
Expression levels in these developing tissues exceed those in adult organs.

Conclusions:

Elevated thrombomodulin expression during development suggests a critical role in embryonic organogenesis.
Findings highlight thrombomodulin's developmental importance beyond its known role in coagulation.