Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

866
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
866
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

1.0K
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
1.0K
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.5K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

616
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
616
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

670
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
670
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

582
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
582

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Menstrual Cycle Phases on Neuromuscular Performance in Elite Adolescent Female Team Sport Athletes.

Journal of strength and conditioning research·2026
Same author

Comparison of External Load Demands Across Three Competitive Tiers in Spanish Football: A Three-Season Single-Club Study.

Journal of strength and conditioning research·2026
Same author

Advancing equity in endometrial cancer: A narrative synthesis using a cluster-informed framework for resource-stratified implementation.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same author

Differential Responsiveness to Exercise and Cognitive Remediation in Physical Health in People With Schizophrenia: Results From the CORTEX-SP Study.

European journal of sport science·2026
Same author

Emotion recognition deficits in Alzheimer's disease: A meta-analysis.

Neuroscience and biobehavioral reviews·2026
Same author

Effects of slow oscillatory HD-tDCS on creative cognition and prefrontal cortex activity: A multimodal EEG-fNIRS study.

Biological psychology·2026
Same journal

Exploratory study to identify facilitators and barriers for implementing a multiplatform communication app for prehospital screening and transfer follow-up in acute stroke.

Medwave·2026
Same journal

Mechanistic analysis of COVID-19 cases in Chile during the second half of 2020: an SIR model with dynamic transmission rate.

Medwave·2026
Same journal

[Abstracts of the4th International Congress on Advances in Nursing and Research. Ambato, Ecuador; May 6-10, 2024].

Medwave·2026
Same journal

Persistent elevated thyroglobulin revealing Struma ovarii in a patient treated for papillary thyroid carcinoma: A case report.

Medwave·2026
Same journal

Why is it essential to teach clinical interviewing in psychiatric training? Proposal for a course implemented at the Universidad de Valparaíso.

Medwave·2026
Same journal

Effects of manual therapy on pain and function in patients with plantar fasciitis: A systematic review of the literature.

Medwave·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

604

Are cannabinoids effective in multiple sclerosis?

Rodrigo Meza1, Javier Peña2, Karen García2

  • 1Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Email: radagabriel@epistemonikos.org. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago Centro, Chile.

Medwave
|March 18, 2017
PubMed
Summary
This summary is machine-generated.

Cannabinoids do not effectively manage multiple sclerosis symptoms like spasticity or pain. This systematic review found they are linked to frequent adverse effects, questioning their clinical use.

More Related Videos

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

3.0K
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Related Experiment Videos

Last Updated: Mar 6, 2026

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

604
Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

3.0K
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Cannabinoids are investigated for potential therapeutic benefits in various conditions.
  • Their efficacy in managing multiple sclerosis (MS) symptoms remains debated.
  • A clear consensus on the clinical role of cannabinoids for MS is lacking.

Purpose of the Study:

  • To systematically evaluate the effectiveness and safety of cannabinoids for multiple sclerosis.
  • To synthesize evidence from existing systematic reviews and randomized trials.

Main Methods:

  • A comprehensive search was conducted in the Epistemonikos database.
  • Data from 25 systematic reviews, encompassing 35 studies (26 randomized trials), were extracted.
  • Meta-analysis and the GRADE approach were employed to assess the evidence quality.

Main Results:

  • Cannabinoids demonstrated no significant reduction in spasticity among multiple sclerosis patients.
  • Pain management was not improved by cannabinoid use in this patient population.
  • Frequent adverse effects were observed in patients using cannabinoids.

Conclusions:

  • Current evidence suggests cannabinoids are ineffective for reducing spasticity and pain in multiple sclerosis.
  • The association with frequent adverse effects raises concerns regarding their therapeutic application in MS.
  • Further research may be needed to clarify the precise role, if any, of cannabinoids in MS management.