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Cutaneous inverted papillomas in dogs.

K L Campbell1, J P Sundberg, M H Goldschmidt

  • 1Department of Veterinary Clinical Medicine, University of Illinois, Urbana.

Veterinary Pathology
|January 1, 1988
PubMed
Summary

Canine inverted papillomas are distinct skin lesions caused by a different papillomavirus type than oral papillomas. These flask-like growths show unique cellular changes and viral presence.

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Area of Science:

  • Veterinary Dermatology
  • Canine Pathology
  • Viral Oncology

Background:

  • Canine inverted papillomas are rare skin tumors.
  • Their etiology and specific causative agents are not fully understood.
  • Distinguishing them from similar lesions like keratoacanthomas is crucial.

Purpose of the Study:

  • To characterize the histopathological and etiological features of canine inverted papillomas.
  • To investigate the potential role of papillomaviruses in these lesions.
  • To differentiate canine inverted papillomas from other cutaneous neoplasms.

Main Methods:

  • Histopathological examination of five canine skin lesions.
  • Immunohistochemical staining for papillomavirus group-specific antigens.
  • Electron microscopy to identify viral particles.
  • In situ DNA hybridization using a canine oral papillomavirus probe.

Main Results:

  • Lesions were circumscribed, flask-like structures with hyperplastic epidermis.
  • Cells showed clear cytoplasm, keratohyalin granules, and intranuclear inclusions.
  • Positive staining for papillomavirus antigens was observed.
  • Electron microscopy revealed virions within cell nuclei.
  • In situ hybridization did not detect canine oral papillomavirus DNA.

Conclusions:

  • Canine inverted papillomas are distinct from canine oral papillomas.
  • A different type of canine papillomavirus is likely responsible for these skin lesions.
  • These findings suggest a unique etiology separate from keratoacanthomas.

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