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Butorphanol in perspective.

C E Rosow1

  • 1Department of Anesthesia, Harvard Medical School, Massachusetts General Hospital, Boston.

Acute Care
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Butorphanol tartrate, an opioid agonist-antagonist, effectively manages severe pain with a favorable safety profile. It offers limited respiratory depression and low abuse potential, making it a valuable analgesic option.

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Area of Science:

  • Pharmacology
  • Anesthesiology
  • Pain Management

Background:

  • Opioid analgesics are crucial for pain management.
  • Opioid agonist-antagonists offer distinct receptor interactions compared to pure agonists.
  • Understanding the unique properties of butorphanol tartrate is essential for its clinical application.

Purpose of the Study:

  • To review the pharmacological and clinical profile of butorphanol tartrate.
  • To highlight its efficacy in pain relief and safety characteristics.
  • To compare its effects with pure opioid agonists.

Main Methods:

  • Review of existing clinical data and pharmacological studies on butorphanol tartrate.
  • Analysis of its receptor binding profile and clinical effects.

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  • Evaluation of safety data, including side effects and potential for abuse.

    • Main Results:

    • Butorphanol tartrate demonstrates effective analgesia for severe pain.
    • It exhibits limited respiratory depression and smooth muscle spasm, reversible with naloxone.
    • Sedation is the most prominent side effect, often beneficial in the perioperative setting.
    • The drug has a low potential for abuse and toxicity.

    Conclusions:

    • Butorphanol tartrate is a safe and effective opioid agonist-antagonist analgesic.
    • Its unique receptor interactions contribute to its distinct clinical profile.
    • Clinical experience supports its utility, particularly in perioperative pain management due to its safety and low abuse potential.