Related Experiment Videos
Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice
G S Kobayashi1, S J Travis, G Medoff
1Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri 63110.
Fluconazole (UK-49,858) was compared with amphotericin B in treating histoplasmosis in female AKR mice immunosuppressed with either cyclophosphamide or cortisone. Both drugs protected animals from a lethal challenge with Histoplasma capsulatum, but neither regimen resulted in cures since viable organisms were cultured from spleens of survivors.
Fluconazole (UK-49,858) was compared with amphotericin B in treating histoplasmosis in female AKR mice immunosuppressed with either cyclophosphamide or cortisone. Both drugs protected animals from a lethal challenge with Histoplasma capsulatum, but neither regimen resulted in cures since viable organisms were cultured from spleens of survivors.