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The signal transducing system coupled to serotonin-S2 receptors
D de Chaffoy de Courcelles1, J E Leysen, F de Clerck
1Department of Biochemistry, Janssen Pharmaceutica Research Laboratories, Beerse, Belgium.
Experientia
|February 15, 1988
Abstract:
The signal transducing system coupled to the serotonin-S2 receptor on platelets involves metabolism of inositol-containing phospholipid, elevation of intracellular free Ca2+ and activation of protein kinase C. Evidence for coupling of the serotonin-S2 receptor to the same signal transducing system in brain and smooth muscle tissue is reviewed.